There are several types of White Blood Cells in the body, each of these cells have a specific function. Learn how the Absolute Eosinophil Count Calculator helps keep a count.
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Absolute Eosinophil Count Calculator
Absolute Eosinophil Count is a measure of eosinophils in your blood. It can be calculated using parameters in a Complete Blood Count (CBC) or Haemogram test.
The body has a group of cells called White Blood Cells (WBCs), which are immune system components. The normal count of total WBCs is between 4,000 - 11,000 cells per microlitre of blood. Several types of White Blood Cells exist in the body, like Neutrophils, Eosinophils, Basophils, Monocytes, and Lymphocytes. Each of these cells has a specific function that contributes to the overall immune status of the body.
Eosinophils are one such type of WBC. Also called Acidophils, the name comes from the fact that these cells are stained with the acidic dye Eosin when the blood sample is prepared for study under the microscope. These cells normally form 1-3% of all white blood cells in the bloodstream.
The Absolute Eosinophil Count (AEC) measures eosinophils in your blood. Eosinophils are a type of white blood cell (WBC) that play a crucial role in the immune system, helping the body fight off infections and mediate allergic responses. The AEC can be calculated using values in a Complete Blood Count (CBC) or Hemogram test.
Eosinophils, also known as acidophils, are a subtype of WBCs. They are stained with acidic eosin, so they appear as a specific colour under a microscope. Typically, eosinophils comprise 1-3% of all white blood cells in the bloodstream.
The Absolute Eosinophil Count Calculator is an online tool that can be used if featured on a reliable website or mobile app.
The count is expressed as the number of cells per microlitre of blood. Doing a CBC (Complete Blood Count) or a Haemogram will provide the values required for this calculation. It can measure the total number of white blood cells called leukocytes. Along with this, the percentage of eosinophils among the WBCs will also be mentioned.
Reference Range
Condition | Range (Number Of Cells/Microlitre) |
---|---|
Normal | 45-450 |
Eosinopenia | Less Than 45 |
Eosinophilia | More Than 500 |
Hypereosinophilia | More Than 1500 |
Sample Calculation:
Total WBC count is 8,000 cells/microlitre
Eosinophil percentage is 2%
Absolute Eosinophil Count = 8000 x 2% = 8000 x 2/100 = 160
Hence, the count is 160 cells per microlitre of blood.
The Absolute Eosinophil Count Calculator is highly accurate based on reliable data from a Complete Blood Count (CBC) or Hemogram test. The calculator simply multiplies the total white blood cell count by the eosinophil percentage, providing an absolute count that matches what a lab would calculate. However, it’s essential to ensure that your WBC count and eosinophil percentage values are correct. For clinical decisions or diagnosis, always consult with a healthcare professional, as other tests and clinical context may be needed to understand your eosinophil count and its implications fully.
Here are the functions of Eosinophils:
Moderating immune reactions against parasitic infections (worm/helminth infections)
Mediating allergic responses & asthmatic reactions (along with mast cells and basophils)
Fighting certain viral and fungal infections
Eosinophils play an important role in asthma, and their concentrations can be correlated to the severity of the disease. Similarly, they mediate other allergic responses in the body. The accumulation of eosinophils in the mucosa of the nose is correlated with a diagnosis of hay fever or allergic rhinitis.
Helminths (parasitic worms) are organisms that mainly cause gastrointestinal diseases. These include tapeworms, roundworms, and flukes. There are numerous species, and most of them enter the gastrointestinal tract through the consumption of food & water that are contaminated with faecal matter. They can also burrow into nearby organs and cause damage to those organs. The immune response to these infections is mediated by eosinophils, & T cells (a type of lymphocytes). An elevated eosinophil count can be seen in these cases.
When eosinophil count is elevated over 500 cells per microlitre, this condition is called Eosinophilia. This most often indicates a parasitic infection or an allergic response in the body. Less commonly, it can be due to some types of cancer.
Depending on the sampling site, Eosinophilia can be either blood eosinophilia or tissue eosinophilia.
Causes of eosinophilia include the following.
Parasitic infections - ascariasis, filariasis, trichinosis etc.
Allergic reactions
Eczema (atopic dermatitis)
Drug allergy
Inflammatory Bowel Disease (ulcerative colitis and Crohn's disease)
Leukaemia (Acute Myeloid Leukaemia)
Hodgkin's Lymphoma
Cancers of other organs, like ovarian cancer
When eosinophil counts exceed 1500 cells per microlitre, it's called Hypereosinophilia. When this is sustained for several months, it is called hypereosinophilic syndrome. This group of disorders can be due to a problem with the production & metabolism of the cells (Primary Hypereosinophilia) or as a response to some disease process (Secondary Hypereosinophilia). These excess eosinophils can cause multi-organ damage, resulting in life-threatening situations if left untreated. The organs that can be affected include skin, heart, lungs, nervous system & digestive tract.
When eosinophil counts are less than 45 cells per microlitre, this condition is called Eosinopenia. It is associated with several conditions like the following.
Sepsis
Inflammation
Use of steroids
Use of medications that treat eosinophil-associated conditions like eosinophilic asthma
In some patients with COVID-19 infection
The Absolute Eosinophil Count is an essential measure for understanding immune responses related to infections and allergies. While calculators provide an estimate, they are not a substitute for medical advice. Elevated or decreased eosinophil levels can signal underlying health issues, making regular monitoring important for effective management and timely intervention. Always consult a healthcare professional for a thorough evaluation.
Calculating the count is important for diagnosing and managing several conditions, such as asthma and allergies. Doctors often advise other investigations like immunoglobulin levels, urine, and stool examinations.
Some people have an allergic diathesis. This means they are more prone to develop asthma, atopic dermatitis (sensitive skin with episodes of rashes), and allergic rhinitis or hay fever (with cold, runny nose, etc.). Your doctor can teach you how to avoid allergens that trigger these conditions and prescribe the same.
Eosinophilia is a condition where eosinophil counts exceed 500 cells per microlitre of blood. Hypereosinophilia is a more severe form, with counts exceeding 1500 cells per microlitre, often leading to tissue or organ damage if untreated.
No specific preparation is required. However, inform your doctor about any medications you’re taking, as steroids and certain drugs may affect your eosinophil levels.
Yes, eosinophil levels can show diurnal variation, typically peaking at night. Factors like stress, infections, or medications may also cause fluctuations.
Disclaimer: The content on this page is generic and shared only for informational and explanatory purposes. Please consult a doctor before making any health-related decisions.